“Hereditary Breast Cancer” Science-Research, April 2022 — summary from NCBI Conserved Domains and NCBI Gene

NCBI Conserved Domains — summary generated by Brevi Assistant

BRCA1, labelled RING finger healthy protein 53, is a RING finger protein encoded by BRCA1, a tumor suppressor gene that regulates all DNA double-strand break fixing pathways. BRCA1 includes an N-terminal C3HC4-type RING-HC finger, and 2 BRCT repeats at the C-terminus. BRCA1 is regularly altered in patients with hereditary breast and ovarian cancer. BRCA1, additionally referred to as RING finger healthy protein 53, is a RING finger healthy protein encoded by growth suppressor gene BRCA1 that manages all DNA double-strand break repair pathways. RING finger is a specific type of Zn-finger of 40 to 60 deposits that binds two atoms of zinc. Not all RING finger-containing proteins display regular RING finger functions, and the RING finger family has turned out to be multifarious. Src Homology 3 domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP concepts. They have been shown to bind peptide series that do not have the PxxP concept; instances include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. Ubiquitin is a healthy protein modifier that is involved in various cellular procedures consisting of transcriptional regulation, cell cycle control, and DNA repair service in eukaryotes. Ubiquitin-like proteins have similar ubiquitin beta-grasp layer and connect to various other healthy proteins in a ubiquitin-like way but with biochemically distinct duties.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

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NCBI Gene — summary generated by Brevi Assistant

This gene encodes a 190 kD nuclear phosphoprotein that plays a function in preserving genomic security, and it also serves as a lump suppressor. The BRCA1 gene has 22 exons extending concerning 110 kb of DNA. Inherited mutations in BRCA1 and this gene, BRCA2, give increased lifetime danger of creating breast or ovarian cancer. The BRCA2 protein includes a number of copies of a 70 aa motif called the BRC theme, and these concepts mediate binding to the RAD51 recombinase which functions in DNA repair work. In response to DNA damages and duplication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. This nuclear healthy protein belongs to the CDS1 subfamily of serine/threonine protein kinases. This gene inscribes an estrogen receptor and ligand-activated transcription variable. The protein centers to the core where it might develop either a homodimer or a heterodimer with estrogen receptor 2. This gene encodes a membrane-bound protein that is a participant of the mucin family. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is included in cell signaling. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. Research on mouse suggests that telomerase also takes part in chromosomal repair work, since de novo synthesis of telomere repeats might happen at double-stranded breaks.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

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The Brevi assistant is a novel way to automatically summarize, assemble, and consolidate multiple text documents, research papers, articles, publications, reports, reviews, feedback, etc., into one compact abstractive form.

At Brevi Assistant, we integrated the most popular open-source databases to empower Researchers, Teachers, and Students to find relevant Contents/Abstracts and to always be up to date about their fields of interest.

Also, users can automate the topics and sources of interest to receive weekly or monthly summaries.

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