“Hereditary Breast Cancer” Science-Research, December 2021 — summary from NCBI Conserved Domains and NCBI Gene

NCBI Conserved Domains — summary generated by Brevi Assistant

BRCA1, additionally called RING finger healthy protein 53, is a RING finger protein inscribed by BRCA1, a tumor suppressor gene that manages all DNA double-strand break repair service pathways. BRCA1 contains an N-terminal C3HC4-type RING-HC finger, and two BRCT repeats at the C-terminus. BRCA1 is often mutated in patients with hereditary breast and ovarian cancer. BRCA1, additionally understood as RING finger healthy protein 53, is a RING finger protein inscribed by lump suppressor gene BRCA1 that controls all DNA double-strand break fixing pathways. The third finger is a customized sort of Zn-finger of 40 to 60 deposits that binds 2 atoms of zinc. Not all RING finger-containing healthy proteins show regular RING finger functions, and the RING finger family has turned out to be multifarious. Src Homology 3 domains are healthy protein communication domains that bind proline-rich ligands with moderate fondness and selectivity, preferentially to PxxP concepts. The SH3 domain having proteins play flexible and diverse roles in the cell, consisting of the regulation of enzymes, altering the subcellular localization of signaling pathway parts, and mediating the formation of multiprotein complex assemblies, amongst others. Ubiquitin is a healthy protein modifier that is associated with various cellular procedures consisting of transcriptional regulation, cell cycle control, and DNA fixing in eukaryotes. Ubiquitin-like healthy proteins have similar ubiquitin beta-grasp fold and affix to various other proteins in a ubiquitin-like fashion yet with biochemically distinctive duties.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

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NCBI Gene — summary generated by Brevi Assistant

This gene encodes a 190 kD nuclear phosphoprotein that plays a function in keeping genomic stability, and it additionally acts as a tumor suppressor. Mutations in this gene are accountable for roughly 40% of inherited breast cancers cells and even more than 80% of inherited breast and ovarian cancers. Acquired mutations in BRCA1 and this gene, BRCA2, have raised the life-time danger of establishing breast or ovarian cancer. BRCA2 is thought to be a lump suppressor gene, as lumps with BRCA2 mutations usually display loss of heterozygosity of the wild-type allele. In response to DNA damage and replication blocks, cell cycle development is halted with the control of critical cell cycle regulators. In addition, this healthy protein engages with and phosphorylates BRCA1, enabling BRCA1 to bring back survival after DNA damage. This gene encodes an estrogen receptor and ligand-activated transcription aspect. The approved protein includes an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. Researches in mouse recommend that telomerase also joins chromosomal fixing, since de novo synthesis of telomere repeats may occur at double-stranded breaks. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. Added isoforms have also been revealed to arise from using alternative translation initiation codons from similar records variants.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

Brief Info about Brevi Assistant

The Brevi assistant is a novel way to automatically summarize, assemble, and consolidate multiple text documents, research papers, articles, publications, reports, reviews, feedback, etc., into one compact abstractive form.

At Brevi Assistant, we integrated the most popular open-source databases to empower Researchers, Teachers, and Students to find relevant Contents/Abstracts and to always be up to date about their fields of interest.

Also, users can automate the topics and sources of interest to receive weekly or monthly summaries.

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Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

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Brevi Assistant

Brevi Assistant

Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

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