“Hereditary Breast Cancer” Science-Research, March 2022 — summary from NCBI Conserved Domains and NCBI Gene

NCBI Conserved Domains — summary generated by Brevi Assistant

BRCA1, additionally described RING finger healthy protein 53, is a RING finger protein inscribed by BRCA1, a growth suppressor genetics that controls all DNA double-strand break repair service pathways. BRCA1 is frequently altered in patients with hereditary breast and ovarian cancer. BRCA1, referred to as RING finger healthy protein 53, is a RING finger protein inscribed by growth suppressor genetics BRCA1 that controls all DNA double-strand break repair work paths. BRCA1 consists of an N-terminal C3HC4-type RING-HC finger, and 2 BRCT repeats at the C-terminus. The RING finger is a specialized kind of Zn-finger of 40 to 60 deposits that binds two atoms of zinc. Nonetheless, not all RING finger-containing healthy proteins display normal RING finger attributes, and the RING finger family has ended up being many. Src Homology 3 domains are protein communication domains that bind proline-rich ligands with moderate fondness and selectivity, preferentially to PxxP motifs. They have been shown to bind peptide sequences that lack the PxxP theme; examples include the PxxDY theme of Eps8 and the RKxxYxxY sequence in SKAP55. Ubiquitin is a healthy protein modifier that is involved in numerous cellular procedures including transcriptional regulation, cell cycle control, and DNA repair service in eukaryotes. Ubiquitin-like proteins have similar ubiquitin beta-grasp layer and affix to various other healthy proteins in a ubiquitin-like manner but with biochemically distinctive roles.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

NCBI Gene — summary generated by Brevi Assistant

This gene encodes a 190 kD nuclear phosphoprotein that plays a function in maintaining genomic security, and it functions as a lump suppressor. Mutations in this gene are liable for roughly 40% of acquired breast cancers cells and greater than 80% of acquired breast and ovarian cancers. Inherited mutations in BRCA1 and this gene, BRCA2, give boosted life time threat of creating breast or ovarian cancer. BRCA2 is taken into consideration as a growth suppressor gene, as tumors with BRCA2 mutations usually show loss of heterozygosity of the wild-type allele. In response to DNA damage and replication blocks, cell cycle development is halted via the control of critical cell cycle regulators. The protein inscribed by this gene is a cell cycle checkpoint regulatory authority and putative tumor suppressor. This gene inscribes an estrogen receptor and ligand-activated transcription factor. The canonical healthy protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. This gene inscribes a membrane-bound protein that is a member of the mucin family. This protein is shared on the apical surface area of epithelial cells that line the mucosal surface areas of many different tissues consisting of lung, breast belly and pancreatic. Telomerase is a ribonucleoprotein polymerase that keeps telomere ends by enhancement of the telomere repeat TTAGGG. Research on mouse suggests that telomerase also joins chromosomal repair work, since afresh synthesis of telomere repeats might occur at double-stranded breaks.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

Brief Info about Brevi Assistant

The Brevi assistant is a novel way to automatically summarize, assemble, and consolidate multiple text documents, research papers, articles, publications, reports, reviews, feedback, etc., into one compact abstractive form.

At Brevi Assistant, we integrated the most popular open-source databases to empower Researchers, Teachers, and Students to find relevant Contents/Abstracts and to always be up to date about their fields of interest.

Also, users can automate the topics and sources of interest to receive weekly or monthly summaries.

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Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

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Brevi Assistant

Brevi Assistant

Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

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