“Hereditary Breast Cancer” Science-Research, October 2021 — summary from NCBI Conserved Domains and NCBI Gene

NCBI Conserved Domains — summary generated by Brevi Assistant

BRCA1, described RING finger healthy protein 53, is a RING finger protein inscribed by BRCA1, a growth suppressor gene that controls all DNA double-strand break repair work paths. BRCA1 consists of an N-terminal C3HC4-type RING-HC finger, and two BRCT repeats at the C-terminus. BRCA1 is often altered in patients with hereditary breast and ovarian cancer. BRCA1, also referred to as RING finger protein 53, is a RING finger healthy protein encoded by lump suppressor gene BRCA1 that controls all DNA double-strand break fixing pathways. The third finger is a customized kind of Zn-finger of 40 to 60 residues that binds 2 atoms of zinc. Nonetheless, not all RING finger-containing healthy proteins present regular RING finger features, and the RING finger family has ended up being many. Src Homology 3 domains are healthy protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They have been shown to bind peptide sequences that lack the PxxP theme; instances include the PxxDY theme of Eps8 and the RKxxYxxY series in SKAP55. Ubiquitin is a protein modifier that is associated with different cellular processes including transcriptional guideline, cell cycle control, and DNA repair in eukaryotes. Ubiquitin-like proteins have similar ubiquitin beta-grasp fold and connect to various other proteins in a ubiquitin-like way however with biochemically distinctive duties.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

NCBI Gene — summary generated by Brevi Assistant

This gene inscribes a 190 kD nuclear phosphoprotein that contributes to maintaining genomic stability, and it also acts as a tumor suppressor. Mutations in this gene are accountable for around 40% of acquired breast cancers and greater than 80% of acquired breast and ovarian cancers. Acquired mutations in BRCA1 and this gene, BRCA2, confer increased lifetime threat of creating breast or ovarian cancer. BRCA2 is considered a tumor suppressor gene, as growths with BRCA2 mutations normally show loss of heterozygosity of the wild-type allele. In response to DNA damages and replication blocks, cell cycle progression is halted via the control of critical cell cycle regulatory authorities. This nuclear healthy protein is a member of the CDS1 subfamily of serine/threonine healthy protein kinases. This gene encodes an estrogen receptor and ligand-activated transcription element. The approved protein includes an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. Telomerase is a ribonucleoprotein polymerase that preserves telomere ends by enhancement of the telomere repeat TTAGGG. Research studies in mouse recommend that telomerase also participates in chromosomal fixing, since de novo synthesis of telomere repeats may occur at double-stranded breaks. This gene inscribes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. Extra isoforms have also been shown to arise from making use of alternating translation initiation codons from the same record versions.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

Brief Info about Brevi Assistant

The Brevi assistant is a novel way to automatically summarize, assemble, and consolidate multiple text documents, research papers, articles, publications, reports, reviews, feedback, etc., into one compact abstractive form.

At Brevi Assistant, we integrated the most popular open-source databases to empower Researchers, Teachers, and Students to find relevant Contents/Abstracts and to always be up to date about their fields of interest.

Also, users can automate the topics and sources of interest to receive weekly or monthly summaries.

--

--

--

Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

Love podcasts or audiobooks? Learn on the go with our new app.

Recommended from Medium

“Kinematics” Science-Research, January 2022, Week 4 — summary from Astrophysics Data System…

IN DEFENCE OF WORMS

“Quantum Field Theory” Science-Research, February 2022 — summary from Astrophysics Data System and…

The Discovery of the Proton

Geiger-Marsden Apparatus

“Multiple Sclerosis” Science-Research, October 2021 — summary from ClinicalTrials.gov,

Beauty of Numbers & Patterns — A World Shaped By Math

Could diamond be the new silicon?

“Matrix Composite ” Science-Research, September 2021 — summary from DOAJ, Astrophysics Data System…

Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store
Brevi Assistant

Brevi Assistant

Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

More from Medium

Going Green(er) with CRISPR Gene Editing

Future museums should be reimagined.

Winter Sports in the Grip of Climate Change

The greatest question in the world