“Hereditary Breast Cancer” Science — Research Papers, August 2021 — summary from NCBI and NCBI Gene.
NCBI — summary generated by Brevi Assistant
BRCA1, also called RING finger healthy protein 53, is a RING finger healthy protein encoded by BRCA1, a tumor suppressor genetics that manages all DNA double-strand break fixing paths. BRCA1 is frequently mutated in patients with hereditary breast and ovarian cancer. BRCA1, also known as RING finger healthy protein 53, is a RING finger healthy protein encoded by tumor suppressor genetics BRCA1 that controls all DNA double-strand break fixing paths. BRCA1 has an N-terminal C3HC4-type RING-HC finger, and 2 BRCT repeats at the C-terminus. RING finger is a specialized type of Zn-finger of 40 to 60 deposits that binds two atoms of zinc. Nevertheless, not all RING finger-containing healthy proteins present normal RING finger attributes, and the RING finger family has become many. Src Homology 3 domains are healthy protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP concepts. Many members of this superfamily are adaptor proteins that link with a number of healthy protein partners, assisting in facility development and signal transduction. Ubiquitin is a protein modifier that is associated with different cellular processes including transcriptional regulation, cell cycle control, and DNA fixing in eukaryotes. Ubiquitin-like proteins have similar ubiquitin beta-grasp fold and connect to other healthy proteins in a ubiquitin-like way however with biochemically distinct roles.
NCBI Gene — summary generated by Brevi Assistant
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in preserving genomic security, and it functions as a tumor suppressor. Anomalies in this gene are in charge of about 40% of inherited breast cancers cells and more than 80% of acquired breast and ovarian cancers cells. Acquired anomalies in BRCA1 and this gene, BRCA2, provide increased life time danger of creating breast or ovarian cancer. The BRCA2 gene was found on chromosome 13q12.3 in human. In response to DNA damages and duplication blocks, cell cycle development is halted via the control of important cell cycle regulatory authorities. This nuclear protein is a participant of the CDS1 subfamily of serine/threonine protein kinases. This gene encodes an estrogen receptor and ligand-activated transcription element. The approved protein contains an N-terminal ligand-independent transactivation domain name, a central DNA binding domain name, a joint domain name, and a C-terminal ligand-dependent transactivation domain name. Telomerase is a ribonucleoprotein polymerase that preserves telomere ends by enhancement of the telomere repeat TTAGGG. Studies in mouse suggest that telomerase takes part in chromosomal fixing, since de novo synthesis of telomere repeats may happen at double-stranded breaks. This gene inscribes a tumor suppressor protein having transcriptional activation, DNA binding, and oligomerization domains. Extra isoforms have also been revealed to arise from making use of alternative translation initiation codons from identical transcript versions.
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