“Molecular Genetics” Science-Research, January 2022, Week 4 — summary from MedlinePlus Genetics and NCBI Conserved Domains

MedlinePlus Genetics — summary generated by Brevi Assistant

Dentatorubral-pallidoluysian atrophy, typically referred to as DRPLA, is a progressive brain disorder that creates involuntary movements, emotional and psychological troubles, and a decrease in thinking capability. The signs and signs and symptoms of DRPLA differ somewhat between affected children and grownups. When DRPLA starts after age 20, one of the most constant indicators and signs and symptoms are ataxia, unmanageable movements of the arm or legs, psychological signs and symptoms such as misconceptions, and deterioration of intellectual function. Familial hypertrophic cardiomyopathy is a heart condition defined by enlarging of the heart muscular tissue. Thickening generally occurs in the interventricular septum, which is the muscular wall that separates the lower left chamber of the heart from the reduced right chamber. People with familial hypertrophic cardiomyopathy have an increased danger of untimely end, even if they have no other signs and symptoms of the condition. Pachyonychia congenita is a condition that largely influences the skin and nails. Almost every person with pachyonychia congenita shows some indications of hypertrophic nail dystrophy, which triggers the fingernails and nails to become thick and extraordinarily formed. Some babies with pachyonychia congenita have prenatal or natal teeth, which are teeth that are present at birth or in very early infancy. Pseudoxanthoma elasticum is a progressive problem that is defined by the build-up of deposits of calcium and various other minerals in flexible fibers. When a joint bends, people with PXE may have yellow-colored bumps called papules on their necks, underarms, and other areas of skin that touch. Mineralization of the capillarys that carry blood from the heart to the rest of the body may cause other symptoms and signs of PXE.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

NCBI Conserved Domains — summary generated by Brevi Assistant

DOMON-like domains can be discovered in all 3 kindgoms of life and are a diverse team of ligand binding domains that have been shown to interact with sugars and hemes. DOMON domains were initially thought to confer protein-protein interactions. They were subsequently located as a heme-binding motif in cellobiose dehydrogenase, an extracellular fungal oxidoreductase that degrades both lignin and cellulose, and in ethylbenzene dehydrogenase, an enzyme that helps in the anaerobic deterioration of hydrocarbons. Research laboratory of Genetics and Physiology 2 is one of 3 participants of the RIG-Ilike Receptor family. RLRs are cytoplasmic RNA receptors that identify non-self RNA and serve as molecular sensing units to discover viral virus. LGP2 might play a regulative function in RLR signaling, and may comply with either RIG-I or MDA5 to feeling viral RNA. Retinoic acid-inducible genetics -Ilike Receptors are cytoplasmic RNA receptors that identify non-self RNA and act as molecular sensing units to detect viral pathogens. Cereblon belongs to an E3 ubiquitin ligase complex, along with damaged DNA binding protein 1, CUL4A and ROC1. The C-terminal domain of Cereblon was revealed to include the binding site for thalidomide and its analogs, a course of teratogenic medications that display an antiproliferative impact on myelomas.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

Brief Info about Brevi Assistant

The Brevi assistant is a novel way to automatically summarize, assemble, and consolidate multiple text documents, research papers, articles, publications, reports, reviews, feedback, etc., into one compact abstractive form.

At Brevi Assistant, we integrated the most popular open-source databases to empower Researchers, Teachers, and Students to find relevant Contents/Abstracts and to always be up to date about their fields of interest.

Also, users can automate the topics and sources of interest to receive weekly or monthly summaries.

--

--

Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store
Brevi Assistant

Brevi Assistant

Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.