“Molecular Genetics” Science-Research, October 2021, Week 4 — summary from PubMed and NCBI Conserved Domains

PubMed — summary generated by Brevi Assistant

Intense myeloid leukemia is one of the most typical severe leukemia in grownups that influences the myeloid family tree. In this evaluation we are reviewing the cytogenetics of AML and the recurrent genetics alterations such as NPM1, FLT3, CEBPA, TET-2, c-KIT, DNMT3A, IDH, RUNX1, AXSL1, WT1, Ras gene mutations etc. AML patients respond to induction radiation treatment initially and ultimately achieve complete remission, ultimately a lot of them get fallen back. Various research studies suggested that the occurrence of specific alleles of the dopamine D2 receptor gene vary throughout various ethnic groups. Hitler’s ‘Brain Washing’ techniques helped his followers to execute genocide at a time when carriers of the DRD2 TaqIA allele were significantly higher amongst the Aryan Germans contrasted to resident German Jews. The hypothesis being that, higher survival might result in improved frequency of not just the DRD2 AI allele but various other reward gene polymorphisms among survivors. Hemophagocytic lymphohistiocytosis is a scientific syndrome of life-threatening inflammation triggered by a too much, prolonged and inefficient immune response. An increasing variety of HLH instances is acknowledged in Poland, however the genetic root causes of domestic HLH have not been reported. Most of FHL patients carried UNC13D pathogenic variants, whereas PRF1 variants took place in two patients.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

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NCBI Conserved Domains — summary generated by Brevi Assistant

DOMON-like domains can be located in all three kindgoms of life and are a diverse team of ligand binding domains that have been revealed to connect with hemes and sugars. DOMON domains were at first assumed to provide protein-protein interactions. The domain connects with sugars in the type 9 carb binding modules, which exist in a variety of glycosyl hydrolases, and it can also be found at the N-terminus of sensing unit histidine kinases. Research laboratory of Genetics and Physiology 2 is among 3 participants of the RIG-Ilike Receptor family. RLRs are cytoplasmic RNA receptors that identify non-self RNA and work as molecular sensing units to identify viral pathogens. LGP2 does not have the caspase activation and recruitment domains that exist in other RLRs, which launch downstream signaling upon viral RNA sensing. Retinoic acid-inducible genetics -Ilike Receptors are cytoplasmic RNA receptors that identify non-self RNA and function as molecular sensing units to find viral pathogens. Cereblon is part of an E3 ubiquitin ligase facility, along with damaged DNA binding protein 1, CUL4A and ROC1. RLRs and Cereblon contain a common conserved zinc binding site in their C-terminal domains.

Please keep in mind that the text is machine-generated by the Brevi Technologies’ Natural language Generation model, and we do not bear any responsibility. The text above has not been edited and/or modified in any way.

Source texts:

Brief Info about Brevi Assistant

The Brevi assistant is a novel way to automatically summarize, assemble, and consolidate multiple text documents, research papers, articles, publications, reports, reviews, feedback, etc., into one compact abstractive form.

At Brevi Assistant, we integrated the most popular open-source databases to empower Researchers, Teachers, and Students to find relevant Contents/Abstracts and to always be up to date about their fields of interest.

Also, users can automate the topics and sources of interest to receive weekly or monthly summaries.

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Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

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Brevi Assistant

Brevi Assistant

Brevi assistant is the world’s first AI technology able to summarize various document types about the same topic with complete accuracy.

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